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Article

Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease.

Nature communications - 14 Dec 2023

Ding Chengyi, Ng Fat Linda, Britton Annie, Im Pek Kei, Lin Kuang, Topiwala Anya, Li Liming, Chen Zhengming, Millwood Iona Y, Bell Steven, Mehta Gautam

Abstract excerpt

Alcohol-related liver disease (ARLD) represents a major public health burden. Identification of high-risk individuals would allow efficient targeting of public health interventions. Here, we show significant interactions between pattern of drinking, genetic predisposition (polygenic risk score, PRS) and diabetes mellitus, and risk of incident ARLD, in 312,599 actively drinking adults in UK Biobank. Binge and...

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Source

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Identifiers

PMID: 38097541
DOI: 10.1038/s41467-023-43064-x
PMCID: PMC10721893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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