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Genetic Discoveries Highlight Environmental Factors as Key Drivers of Liver Disease.

Digestive diseases (Basel, Switzerland) - 1 Jan 2017

Chung Brian K, Karlsen Tom H

Abstract excerpt

BACKGROUND: Over the last 50 years, genetic studies have uncovered a spectrum of rare and common alleles that confer susceptibility to both Mendelian and complex forms of liver disease. For disorders of Mendelian inheritance, identification of the causal variants has demonstrated that common environmental exposures can elicit severe liver pathogenesis in predisposed individuals. Specific environmental triggers...

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PMID: 28468012
DOI: 10.1159/000456583

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