A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers.

doi:10.1016/j.jhep.2021.10.005

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Article

A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers.

Journal of hepatology - 1 Feb 2022

Whitfield John B, Schwantes-An Tae-Hwi, Darlay Rebecca, Aithal Guruprasad P, Atkinson Stephen R, Bataller Ramon, Botwin Greg, Chalasani Naga P, Cordell Heather J, Daly Ann K, Day Christopher P, Eyer Florian, Foroud Tatiana, Gleeson Dermot, Goldman David, Haber Paul S, Jacquet Jean-Marc, Liang Tiebing, Liangpunsakul Suthat, Masson Steven, Mathurin Philippe, Moirand Romain, McQuillin Andrew, Moreno Christophe, Morgan Marsha Y, Mueller Sebastian, Müllhaupt Beat, Nagy Laura E, Nahon Pierre, Nalpas Bertrand, Naveau Sylvie, Perney Pascal, Pirmohamed Munir, Seitz Helmut K, Soyka Michael, Stickel Felix, Thompson Andrew, Thursz Mark R, Trépo Eric, Morgan Timothy R, Seth Devanshi

Abstract excerpt

BACKGROUND & AIMS: Only a minority of excess alcohol drinkers develop cirrhosis. We developed and evaluated risk stratification scores to identify those at highest risk. METHODS: Three cohorts (GenomALC-1: n = 1,690, GenomALC-2: n = 3,037, UK Biobank: relevant n = 6,898) with a history of heavy a...

Topics

Adult
Alcohol Drinking
Case-Control Studies
Cohort Studies
Diabetes Mellitus
Female
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Humans

Liver Cirrhosis, Alcoholic

Male

Middle Aged

Polymorphism, Single Nucleotide

Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 34656649
DOI: 10.1016/j.jhep.2021.10.005
PMCID: PMC8803006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-34656649-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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