Article
Polygenic risk score of metabolic dysfunction-associated steatotic liver disease amplifies the health impact on severe liver disease and metabolism-related outcomes.
Journal of translational medicine - 12 Jul 2024
Xiao Lushan, Li Yan, Hong Chang, Ma Pengcheng, Zhu Hongbo, Cui Hao, Zou Xuejing, Wang Jiaren, Li Ruining, He Jingzhe, Liang Shengxing, Li Zeyang, Zeng Lin, Liu Li
Abstract excerpt
BACKGROUND: Although the inherited risk factors associated with fatty liver disease are well understood, little is known about the genetic background of metabolic dysfunction-associated steatotic liver disease (MASLD) and its related health impacts. Compared to non-alcoholic fatty liver disease (NAFLD), MASLD presents significantly distinct diagnostic criteria, and epidemiological and clinical features, but the...
Topics
- Humans
- Polymorphism, Single Nucleotide
- Male
- Female
- Genome-Wide Association Study
- Multifactorial Inheritance
- Risk Factors
- Middle Aged
- Genetic Predisposition to Disease