Article
Association of Homologous Recombination-DNA Damage Response Gene Mutations with Immune Biomarkers in Gastroesophageal Cancers.
Molecular cancer therapeutics - 1 Jan 2022
Cerniglia Michael, Xiu Joanne, Grothey Axel, Pishvaian Michael J, Baca Yasmine, Hwang Jimmy J, Marshall John L, VanderWalde Ari M, Shields Anthony F, Lenz Heinz-Josef, Korn W Michael, Salem Mohamed, Philip Philip A, Goldberg Richard M, Zeng Jia, Kim Sunnie S
Abstract excerpt
The prevalence of homologous recombination-DNA damage response (HR-DDR) genetic alterations is of therapeutic interest in gastroesophageal cancers. This study is a comprehensive assessment of HR-DDR mutation prevalence across gastroesophageal adenocarcinomas and squamous cell carcinomas. Here we investigate the association of HR-DDR mutations with known predictors for immune-checkpoint inhibition [deficiency in...
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