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Article

Profiling of the genetic features of Chinese patients with gastric cancer with HRD germline mutations in a large-scale retrospective study.

Journal of medical genetics - 1 Aug 2023

Zhang Chenghai, Zhu Dandan, Qu Yurong, Shi Min, Ma Jingjiao, Peng Yebo, Zhu Bowen, Tao Houquan, Ma Tonghui, Hou TieYing

Abstract excerpt

BACKGROUND: Approximately 10% of gastric cancers (GCs) are associated with strong familial clustering and can be attributed to genetic predisposition. Homologous recombination deficiency (HRD) leads to genomic instability and accumulation of genetic variations, playing an important role in the development and progression of cancer. We aimed to delineate the germline mutation characteristics of patients with...

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Identifiers

PMID: 36627197
DOI: 10.1136/jmg-2022-108816
PMCID: PMC10423538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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