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The prognostic and predictive value of homologous recombination deficiency in gastrointestinal cancer

1 Jun 2025

Abstract excerpt

The homologous recombination (HR) system repairs DNA double-strand breaks produced by the DNA damage response, which is a complex signaling pathway consisting of the key proteins BRCA1/2 and other DNA repair proteins, such as the ATM, PALB2, BARD1, RAD51, and Fanconi anemia proteins. Mutations and epigenetic alterations in HR-related genes may lead to homologous recombination deficiency (HRD), resulting in...

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PMID: 40515474
DOI: 10.1093/oncolo/oyaf141

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