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Article

Homologous recombination deficiency (HRD) is associated with better prognosis and possibly causes a non-inflamed tumour microenvironment in nasopharyngeal carcinoma.

The journal of pathology. Clinical research - 1 Sept 2024

Zhou Xinyi, Ying Haoxuan, Sun Yujie, Zhang Wenda, Luo Peng, Zhu Shuhan, Zhang Jian

Abstract excerpt

Homologous recombination deficiency (HRD) score is a reliable indicator of genomic instability. The significance of HRD in nasopharyngeal carcinoma (NPC), particularly its influence on prognosis and the immune microenvironment, has yet to be adequately explored. Understanding HRD status comprehensively can offer valuable insights for guiding precision treatment. We utilised three cohorts to investigate HRD status...

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Identifiers

PMID: 39104056
DOI: 10.1002/2056-4538.12391
PMCID: PMC11300531

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BRCA1

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