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Mutational landscape of DNA damage response deficiency-related genes and its association with immune biomarkers in esophageal squamous cell carcinoma.

Neoplasma - 1 Dec 2022

Chen Gang, Zhu Yong-Jun, Chen Ji, Miao Feng, Wu Ning, Song Yang, Mao Bei-Bei, Wang Sheng-Zhou, Xu Fei, Chen Zhi-Ming

Abstract excerpt

Esophageal squamous cell carcinoma (ESCC) has limited effective treatment strategies. DNA damage response (DDR) genes are of therapeutic interest in multiple cancer types. This study aimed to depict the landscape of DDR mutations in ESCC and evaluate the association between DDR mutations and known immunotherapy biomarkers. We recruited 250 Chinese patients with ESCC and performed next-generation sequencing. A...

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PMID: 36264776
DOI: 10.4149/neo_2022_220721N738

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