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Article

gpps: an ILP-based approach for inferring cancer progression with mutation losses from single cell data.

BMC bioinformatics - 9 Dec 2020

Ciccolella Simone, Soto Gomez Mauricio, Patterson Murray D, Della Vedova Gianluca, Hajirasouliha Iman, Bonizzoni Paola

Abstract excerpt

BACKGROUND: Cancer progression reconstruction is an important development stemming from the phylogenetics field. In this context, the reconstruction of the phylogeny representing the evolutionary history presents some peculiar aspects that depend on the technology used to obtain the data to analyze: Single Cell DNA Sequencing data have great specificity, but are affected by moderate false negative and missing...

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PMID: 33297943
DOI: 10.1186/s12859-020-03736-7
PMCID: PMC7725124

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