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Distinguishing linear and branched evolution given single-cell DNA sequencing data of tumors

6 Jul 2021

Abstract excerpt

BACKGROUND: Cancer arises from an evolutionary process where somatic mutations give rise to clonal expansions. Reconstructing this evolutionary process is useful for treatment decision-making as well as understanding evolutionary patterns across patients and cancer types. In particular, classifying a tumor's evolutionary process as either linear or branched and understanding what cancer types and which patients...

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PMID: 34229713
DOI: 10.1186/s13015-021-00194-5

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