Article
Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type 1 diabetes.
The Journal of experimental medicine - 1 Mar 2021
Kim Heejoo, Perovanovic Jelena, Shakya Arvind, Shen Zuolian, German Cody N, Ibarra Andrea, Jafek Jillian L, Lin Nai-Pin, Evavold Brian D, Chou Danny H-C, Jensen Peter E, He Xiao, Tantin Dean
Abstract excerpt
The transcriptional coregulator OCA-B promotes expression of T cell target genes in cases of repeated antigen exposure, a necessary feature of autoimmunity. We hypothesized that T cell-specific OCA-B deletion and pharmacologic OCA-B inhibition would protect mice from autoimmune diabetes. We developed an Ocab conditional allele and backcrossed it onto a diabetes-prone NOD/ShiLtJ strain background. T cell-specific...
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