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Article

Regulation of Foxo1 expression is critical for central B cell tolerance and allelic exclusion.

Cell reports - 25 Jun 2024

McCaleb Megan R, Miranda Anjelica M, Khammash Hadeel A, Torres Raul M, Pelanda Roberta

Abstract excerpt

Resolving the molecular mechanisms of central B cell tolerance might unveil strategies that prevent autoimmunity. Here, using a mouse model of central B cell tolerance in which Forkhead box protein O1 (Foxo1) is either deleted or over-expressed in B cells, we show that deleting Foxo1 blocks receptor editing, curtails clonal deletion, and decreases CXCR4 expression, allowing high-avidity autoreactive B cells to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38796853
DOI: 10.1016/j.celrep.2024.114283
PMCID: PMC11246624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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