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Chromosomal aberration arises during somatic reprogramming to pluripotent stem cells

3 Nov 2020

Abstract excerpt

BACKGROUND: Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has opened new therapeutic possibilities. However, karyotypic abnormalities detected in iPSCs compromised their utility, especially chromosomal aberrations found at early passages raised serious safety concerns. The mechanism underlying the chromosomal abnormality in early-passage iPSCs is not known. METHODS: Human dermal...

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PMID: 33292330
DOI: 10.1186/s13008-020-00068-z

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