Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state.

Abstract excerpt

Induced pluripotent stem cells (iPSCs) hold great promise for personalized regenerative medicine. However, recent studies show that iPSC lines carry genetic abnormalities, suggesting that reprogramming may be mutagenic. Here, we show that the ectopic expression of reprogramming factors increases the level of phosphorylated histone H2AX, one of the earliest cellular responses to DNA double-strand breaks (DSBs)....

Topics

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• Apoptosis
• Cellular Reprogramming
• DNA Breaks, Double-Stranded
• Gene Deletion
• Genes, p53