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Induced pluripotent stem cells: opportunities and challenges

4 Jul 2011

Abstract excerpt

Somatic cells have been reprogrammed into pluripotent stem cells by introducing a combination of several transcription factors, such as Oct3/4, Sox2, Klf4 and c-Myc. Induced pluripotent stem (iPS) cells from a patient's somatic cells could be a useful source for drug discovery and cell transplantation therapies. However, most human iPS cells are made by viral vectors, such as retrovirus and lentivirus, which...

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PMID: 21727125
DOI: 10.1098/rstb.2011.0016

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