Article
ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors.
Nature cell biology - 1 Sept 2017
Skamagki Maria, Correia Cristina, Yeung Percy, Baslan Timour, Beck Samuel, Zhang Cheng, Ross Christian A, Dang Lam, Liu Zhong, Giunta Simona, Chang Tzu-Pei, Wang Joye, Ananthanarayanan Aparna, Bohndorf Martina, Bosbach Benedikt, Adjaye James, Funabiki Hironori, Kim Jonghwan, Lowe Scott, Collins James J, Lu Chi-Wei, Li Hu, Zhao Rui, Kim Kitai
Abstract excerpt
Induced pluripotent stem cells (iPSCs), which are used to produce transplantable tissues, may particularly benefit older patients, who are more likely to suffer from degenerative diseases. However, iPSCs generated from aged donors (A-iPSCs) exhibit higher genomic instability, defects in apoptosis and a blunted DNA damage response compared with iPSCs generated from younger donors. We demonstrated that A-iPSCs...
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