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Article

A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2021

Sun Dayan, Niu Zhenmin, Zheng Hong-Xiang, Wu Fei, Jiang Liuyiqi, Han Tian-Quan, Wei Yang, Wang Jiucun, Jin Li

Abstract excerpt

BACKGROUND AND AIMS: Gallstone disease (cholelithiasis) is a cholesterol-related metabolic disorders with strong familial predisposition. Mitochondrial DNA (mtDNA) variants accumulated during human evolution are associated with some metabolic disorders related to modified mitochondrial function. The mechanistic links between mtDNA variants and gallstone formation need further exploration. METHODS: In this study,...

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Identifiers

PMID: 33279689
DOI: 10.1016/j.jcmgh.2020.11.015
PMCID: PMC8053626

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