Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition.

doi:10.1053/j.gastro.2010.09.003

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Article

Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition.

Gastroenterology - 1 Dec 2010

Buch Stephan, Schafmayer Clemens, Völzke Henry, Seeger Marcus, Miquel Juan F, Sookoian Silvia C, Egberts Jan H, Arlt Alexander, Pirola Carlos J, Lerch Markus M, John Ulrich, Franke Andre, von Kampen Oliver, Brosch Mario, Nothnagel Michael, Kratzer Wolfgang, Boehm Bernhard O, Bröring Dieter C, Schreiber Stefan, Krawczak Michael, Hampe Jochen

Abstract excerpt

BACKGROUND & AIMS: Genome-wide association studies have mapped loci that are associated with serum levels of bilirubin. Bilirubin is a major component of gallstones so we investigated whether these variants predict gallstone bilirubin content and overall risk for gallstones. METHODS: Loci that were identified in a meta-analysis to attain a genome-wide significance level of a P value less than 1.0×10(-7) (UGT1A1,...

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PMID: 20837016
DOI: 10.1053/j.gastro.2010.09.003

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ABCG8

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