Article
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease.
Nature genetics - 1 Aug 2007
Buch Stephan, Schafmayer Clemens, Völzke Henry, Becker Christian, Franke Andre, von Eller-Eberstein Huberta, Kluck Christian, Bässmann Ingelore, Brosch Mario, Lammert Frank, Miquel Juan Francisco, Nervi Flavio, Wittig Michael, Rosskopf Dieter, Timm Birgit, Höll Christine, Seeger Marcus, ElSharawy Abdou, Lu Tim, Egberts Jan, Fändrich Fred, Fölsch Ulrich R, Krawczak Michael, Schreiber Stefan, Nürnberg Peter, Tepel Jürgen, Hampe Jochen
Abstract excerpt
With an overall prevalence of 10-20%, gallstone disease (cholelithiasis) represents one of the most frequent and economically relevant health problems of industrialized countries. We performed an association scan of >500,000 SNPs in 280 individuals with gallstones and 360 controls. A follow-up study of the 235 most significant SNPs in 1,105 affected individuals and 873 controls replicated the disease association...
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