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Article

Risk of gallstones based on ABCG8 rs11887534 single nucleotide polymorphism among Taiwanese men and women.

BMC gastroenterology - 14 Dec 2021

Liang Keng-Wei, Huang Hsin-Hui, Wang Lee, Lu Wen-Yu, Chou Ying-Hsiang, Tantoh Disline Manli, Nfor Oswald Ndi, Chiu Neng-Yu, Tyan Yeu-Sheng, Liaw Yung-Po

Abstract excerpt

BACKGROUND: Gallstones are abnormal masses caused by impaired metabolism of cholesterol, bilirubin, or bile salts in the gallbladder or biliary tract. ATP-binding cassette subfamily G member 8 (ABCG8) is a protein that regulates cholesterol efflux from the liver. Genome-wide association studies (GWAS) and meta-analyses of GWAS revealed the ABCG8 rs11887534 variant as the most common genetic determinant of...

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PMID: 34906072
DOI: 10.1186/s12876-021-02060-5
PMCID: PMC8672562

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