Article
Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies.
Gastroenterology - 1 Aug 2016
Joshi Amit D, Andersson Charlotte, Buch Stephan, Stender Stefan, Noordam Raymond, Weng Lu-Chen, Weeke Peter E, Auer Paul L, Boehm Bernhard, Chen Constance, Choi Hyon, Curhan Gary, Denny Joshua C, De Vivo Immaculata, Eicher John D, Ellinghaus David, Folsom Aaron R, Fuchs Charles, Gala Manish, Haessler Jeffrey, Hofman Albert, Hu Frank, Hunter David J, Janssen Harry L A, Kang Jae H, Kooperberg Charles, Kraft Peter, Kratzer Wolfgang, Lieb Wolfgang, Lutsey Pamela L, Darwish Murad Sarwa, Nordestgaard Børge G, Pasquale Louis R, Reiner Alex P, Ridker Paul M, Rimm Eric, Rose Lynda M, Shaffer Christian M, Schafmayer Clemens, Tamimi Rulla M, Uitterlinden André G, Völker Uwe, Völzke Henry, Wakabayashi Yoshiyuki, Wiggs Janey L, Zhu Jun, Roden Dan M, Stricker Bruno H, Tang Weihong, Teumer Alexander, Hampe Jochen, Tybjærg-Hansen Anne, Chasman Daniel I, Chan Andrew T, Johnson Andrew D
Abstract excerpt
BACKGROUND & AIMS: A genome-wide association study (GWAS) of 280 cases identified the hepatic cholesterol transporter ABCG8 as a locus associated with risk for gallstone disease, but findings have not been reported from any other GWAS of this phenotype. We performed a large-scale, meta-analysis of GWASs of individuals of European ancestry with available prior genotype data, to identify additional genetic risk...
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