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Article

Implications of Polymorphisms in the BCKDK and GATA-4 Gene Regions on Stable Warfarin Dose in African Americans.

Clinical and translational science - 1 Mar 2021

Bargal Salma A, Kight Jennifer N, Augusto de Oliveira Felipe, Shahin Mohamed H, Langaee Taimour, Gong Yan, Hamadeh Issam S, Cooper-DeHoff Rhonda M, Cavallari Larisa H

Abstract excerpt

VKORC1 and CYP2C9 genotypes explain less variability in warfarin dose requirements in African Americans compared with Europeans. Variants in BCKDK and GATA-4 gene regions, purported to regulate VKORC1 and CYP2C9 expression, have been shown to play an important role in warfarin dose requirements in Europeans and Asians, respectively. We sought to determine whether rs56314408 near BCKDK or GATA-4 rs2645400...

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Source

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Identifiers

PMID: 33278335
DOI: 10.1111/cts.12939
PMCID: PMC7993290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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