Genetic Factors Influencing Warfarin Dose in Black-African Patients: A Systematic Review and Meta-Analysis.

doi:10.1002/cpt.1755

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Genetic Factors Influencing Warfarin Dose in Black-African Patients: A Systematic Review and Meta-Analysis.

Clinical pharmacology and therapeutics - 1 Jun 2020

Asiimwe Innocent G, Zhang Eunice J, Osanlou Rostam, Krause Amanda, Dillon Chrisly, Suarez-Kurtz Guilherme, Zhang Honghong, Perini Jamila A, Renta Jessicca Y, Duconge Jorge, Cavallari Larisa H, Marcatto Leiliane R, Beasly Mark T, Perera Minoli A, Limdi Nita A, Santos Paulo C J L, Kimmel Stephen E, Lubitz Steven A, Scott Stuart A, Kawai Vivian K, Jorgensen Andrea L, Pirmohamed Munir

Abstract excerpt

Warfarin is the most commonly used oral anticoagulant in sub-Saharan Africa. Dosing is challenging due to a narrow therapeutic index and high interindividual variability in dose requirements. To evaluate the genetic factors affecting warfarin dosing in black-Africans, we performed a meta-analysis of 48 studies (2,336 patients). Significant predictors for CYP2C9 and stable dose included rs1799853 (CYP2C9*2),...

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Identifiers

PMID: 31869433
DOI: 10.1002/cpt.1755
PMCID: PMC7217737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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