Article
Factors influencing warfarin dose requirements in African-Americans.
Pharmacogenomics - 1 Nov 2007
Momary Kathryn M, Shapiro Nancy L, Viana Marlos Ag, Nutescu Edith A, Helgason Cathy M, Cavallari Larisa H
Abstract excerpt
INTRODUCTION: African-Americans are under-represented in studies assessing contributors to warfarin response. Our primary objective was to determine whether the genes for cytochrome P450 (CYP) 2C9, nicotinamide adenine dinucleotide phosphate, reduced, quinone oxidoreductase (NQO1) and vitamin K epoxide reductase complex subunit 1 (VKORC1) are associated with warfarin dose requirements in African-Americans....
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