Article

Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage

2019-11-04

Abstract excerpt

TYK2 belongs to the JAK protein tyrosine kinase family and mediates signaling of numerous antiviral and immunoregulatory cytokines (type I and type III IFNs, IL-10, IL-12, IL-22, IL-23) in immune and non-immune cells. After many years of genetic association studies, TYK2 is recognized as a susceptibility gene for some inflammatory and autoimmune diseases (AID). Seven TYK2 variants have been associated with AIDs...

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Literature Corpus work: 450f2a6c-14b8-503e-a31f-677326d8f28f
DOI: 10.1101/830232

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