Article
TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia.
Cancer discovery - 1 May 2013
Sanda Takaomi, Tyner Jeffrey W, Gutierrez Alejandro, Ngo Vu N, Glover Jason, Chang Bill H, Yost Arla, Ma Wenxue, Fleischman Angela G, Zhou Wenjun, Yang Yandan, Kleppe Maria, Ahn Yebin, Tatarek Jessica, Kelliher Michelle A, Neuberg Donna S, Levine Ross L, Moriggl Richard, Müller Mathias, Gray Nathanael S, Jamieson Catriona H M, Weng Andrew P, Staudt Louis M, Druker Brian J, Look A Thomas
Abstract excerpt
UNLABELLED: Targeted molecular therapy has yielded remarkable outcomes in certain cancers, but specific therapeutic targets remain elusive for many others. As a result of two independent RNA interference (RNAi) screens, we identified pathway dependence on a member of the Janus-activated kinase (JAK) tyrosine kinase family, TYK2, and its downstream effector STAT1, in T-cell acute lymphoblastic leukemia (T-ALL)....
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