Article
Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells.
Nature communications - 14 Jan 2015
Küçük Can, Jiang Bei, Hu Xiaozhou, Zhang Wenyan, Chan John K C, Xiao Wenming, Lack Nathan, Alkan Can, Williams John C, Avery Kendra N, Kavak Pınar, Scuto Anna, Sen Emel, Gaulard Philippe, Staudt Lou, Iqbal Javeed, Zhang Weiwei, Cornish Adam, Gong Qiang, Yang Qunpei, Sun Hong, d'Amore Francesco, Leppä Sirpa, Liu Weiping, Fu Kai, de Leval Laurence, McKeithan Timothy, Chan Wing C
Abstract excerpt
Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and STAT5B in NK/T-cell lymphomas (n=51), γδ-T-cell lymphomas (n=43) and their cell lines (n=9) through next generation and/or Sanger sequencing. STAT5B N642H is particularly frequent in all forms of γδ-T-cell lymphomas. STAT3 and STAT5B...
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