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Janus Kinases in Leukemia

14 Feb 2021

Abstract excerpt

Janus kinases (JAKs) transduce signals from dozens of extracellular cytokines and function as critical regulators of cell growth, differentiation, gene expression, and immune responses. Deregulation of JAK/STAT signaling is a central component in several human diseases including various types of leukemia and other malignancies and autoimmune diseases. Different types of leukemia harbor genomic aberrations in all...

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PMID: 33672930
DOI: 10.3390/cancers13040800

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