Article
cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes.
Genome biology - 16 Mar 2017
Li Mulin Jun, Li Miaoxin, Liu Zipeng, Yan Bin, Pan Zhicheng, Huang Dandan, Liang Qian, Ying Dingge, Xu Feng, Yao Hongcheng, Wang Panwen, Kocher Jean-Pierre A, Xia Zhengyuan, Sham Pak Chung, Liu Jun S, Wang Junwen
Abstract excerpt
It remains challenging to predict regulatory variants in particular tissues or cell types due to highly context-specific gene regulation. By connecting large-scale epigenomic profiles to expression quantitative trait loci (eQTLs) in a wide range of human tissues/cell types, we identify critical chromatin features that predict variant regulatory potential. We present cepip, a joint likelihood framework, for...
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