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Cancer Evolution: A Multifaceted Affair

4 Dec 2023

Abstract excerpt

Cancer cells adapt and survive through the acquisition and selection of molecular modifications. This process defines cancer evolution. Building on a theoretical framework based on heritable genetic changes has provided insights into the mechanisms supporting cancer evolution. However, cancer hallmarks also emerge via heritable nongenetic mechanisms, including epigenetic and chromatin topological changes, and...

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PMID: 38047596
DOI: 10.1158/2159-8290.cd-23-0530

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