Article
Evolution of the cancer genome.
Nature reviews. Genetics - 1 Nov 2012
Yates Lucy R, Campbell Peter J
Abstract excerpt
The advent of massively parallel sequencing technologies has allowed the characterization of cancer genomes at an unprecedented resolution. Investigation of the mutational landscape of tumours is providing new insights into cancer genome evolution, laying bare the interplay of somatic mutation, adaptation of clones to their environment and natural selection. These studies have demonstrated the extent of the...
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