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Article

Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium.

Molecular and cellular biology - 25 Jan 2021

Horiuchi Makoto, Taguchi Keiko, Hirose Wataru, Tsuchida Kouhei, Suzuki Mikiko, Taniyama Yusuke, Kamei Takashi, Yamamoto Masayuki

Abstract excerpt

Nrf2 is essential for cytoprotection against carcinogens, and through systemic Nrf2 knockout mice, Nrf2-deficient cells were shown to be susceptible to chemical carcinogens and prone to developing cancers. However, the oncogenic potential of Nrf2-deficient epithelial cells surrounded by normal cells in the esophagus could not be assessed by previous models, and the fate of Nrf2-deficient cells in such situations...

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Source

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Identifiers

PMID: 33257504
DOI: 10.1128/MCB.00536-20
PMCID: PMC8093497

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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