Article
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2001
Ramos-Gomez M, Kwak M K, Dolan P M, Itoh K, Yamamoto M, Talalay P, Kensler T W
Abstract excerpt
Induction of phase 2 enzymes, which neutralize reactive electrophiles and act as indirect antioxidants, appears to be an effective means for achieving protection against a variety of carcinogens in animals and humans. Transcriptional control of the expression of these enzymes is mediated, at least in part, through the antioxidant response element (ARE) found in the regulatory regions of their genes. The...
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