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Article

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2001

Ramos-Gomez M, Kwak M K, Dolan P M, Itoh K, Yamamoto M, Talalay P, Kensler T W

Abstract excerpt

Induction of phase 2 enzymes, which neutralize reactive electrophiles and act as indirect antioxidants, appears to be an effective means for achieving protection against a variety of carcinogens in animals and humans. Transcriptional control of the expression of these enzymes is mediated, at leas...

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Source

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Identifiers

PMID: 11248092
DOI: 10.1073/pnas.051618798
PMCID: PMC30667

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11248092-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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