Article
A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue.
The Journal of pathology - 1 Oct 2020
Bowman Brittany M, Montgomery Stephanie A, Schrank Travis P, Simon Jeremy M, Ptacek Travis S, Tamir Tigist Y, Mulvaney Kathleen M, Weir Seth J, Nguyen Tuong T, Murphy Ryan M, Makowski Liza, Hayes D Neil, Chen Xiaoxin L, Randell Scott H, Weissman Bernard E, Major Michael B
Abstract excerpt
Activation of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2) transcription factor is a critical and evolutionarily conserved cellular response to oxidative stress, metabolic stress, and xenobiotic insult. Deficiency of NRF2 results in hypersensitivity to a variety of stressors, whereas its aberrant activation contributes to several cancer types, most commonly squamous cell carcinomas of the...
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