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Article

Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis.

Genes & development - 15 May 2010

Schäfer Matthias, Dütsch Sabine, auf dem Keller Ulrich, Navid Fatemeh, Schwarz Agatha, Johnson Delinda A, Johnson Jeffrey A, Werner Sabine

Abstract excerpt

Ultraviolet (UV) B irradiation can severely damage the skin and even induce tumorigenesis. It exerts its effects by direct DNA modification and by formation of reactive oxygen species (ROS). We developed a strategy to genetically activate target gene expression of the transcription factor NF-E2-related factor 2 (Nrf2) in keratinocytes in vivo based on expression of a constitutively active Nrf2 mutant. Activation...

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Source

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Identifiers

PMID: 20478997
DOI: 10.1101/gad.568810
PMCID: PMC2867209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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