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Article

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice.

The Journal of clinical investigation - 1 Nov 2004

Rangasamy Tirumalai, Cho Chung Y, Thimmulappa Rajesh K, Zhen Lijie, Srisuma Sorachai S, Kensler Thomas W, Yamamoto Masayuki, Petrache Irina, Tuder Rubin M, Biswal Shyam

Abstract excerpt

Although inflammation and protease/antiprotease imbalance have been postulated to be critical in cigarette smoke-induced (CS-induced) emphysema, oxidative stress has been suspected to play an important role in chronic obstructive pulmonary diseases. Susceptibility of the lung to oxidative injury, such as that originating from inhalation of CS, depends largely on its upregulation of antioxidant systems. Nuclear...

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Identifiers

PMID: 15520857
DOI: 10.1172/JCI21146
PMCID: PMC524225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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