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Article

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.

Nature genetics - 1 Nov 2003

Wakabayashi Nobunao, Itoh Ken, Wakabayashi Junko, Motohashi Hozumi, Noda Shuhei, Takahashi Satoru, Imakado Sumihisa, Kotsuji Tomoe, Otsuka Fujio, Roop Dennis R, Harada Takanori, Engel James Douglas, Yamamoto Masayuki

Abstract excerpt

Transcription factor Nrf2 (encoded by Nfe2l2) regulates a battery of detoxifying and antioxidant genes, and Keap1 represses Nrf2 function. When we ablated Keap1, Keap1-deficient mice died postnatally, probably from malnutrition resulting from hyperkeratosis in the esophagus and forestomach. Nrf2 activity affects the expression levels of several squamous epithelial genes. Biochemical data show that, without Keap1,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 14517554
DOI: 10.1038/ng1248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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