Mycobacterium tuberculosis functional genetic diversity, altered drug sensitivity, and precision medicine.

doi:10.3389/fcimb.2022.1007958

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Article

Mycobacterium tuberculosis functional genetic diversity, altered drug sensitivity, and precision medicine.

Frontiers in cellular and infection microbiology - 1 Jan 2022

Stanley Sydney, Liu Qingyun, Fortune Sarah M

Abstract excerpt

In the face of the unrelenting global burden of tuberculosis (TB), antibiotics remain our most effective tools to save lives and control the spread of Mycobacterium tuberculosis (Mtb). However, we confront a dual challenge in our use of antibiotics: simplifying and shortening the TB drug regimen while also limiting the emergence and propagation of antibiotic resistance. This task is now more feasible due to the...

Topics

Humans
Mycobacterium tuberculosis
Antitubercular Agents
Precision Medicine
Tuberculosis, Lymph Node
Microbial Sensitivity Tests
Genetic Variation
Drug Resistance

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Identifiers

PMID: 36262182
DOI: 10.3389/fcimb.2022.1007958
PMCID: PMC9574059

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