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Article

A T‐cell reporter platform for high‐throughput and reliable investigation of TCR function and biology

1 Jan 2020

Abstract excerpt

Abstract Objective Transgenic re‐expression enables unbiased investigation of T‐cell receptor (TCR)‐intrinsic characteristics detached from its original cellular context. Recent advancements in TCR repertoire sequencing and development of protocols for direct cloning of full TCRαβ constructs now facilitate large‐scale transgenic TCR re‐expression. Together, this offers unprecedented opportunities for the...

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PMID: 33251011
DOI: 10.1002/cti2.1216

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