Article

Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy

2020-12-14

Abstract excerpt

Adoptive transfer of T cells expressing a transgenic T cell receptor (TCR) has the potential to revolutionize immunotherapy of infectious diseases and cancer. However, the generation of defined TCR-transgenic T cell medicinal products with predictable in vivo function still poses a major challenge and limits broader and more successful application of this ‘living drug’. Here, by studying 51 different TCRs, we show...

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Literature Corpus work: 28f6a18c-ae61-55d9-aa3a-757ea1f614cd
DOI: 10.1101/2020.12.14.20248169

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