Article

Reprogramming human T cell function and specificity with non-viral genome targeting

2017-08-31

Abstract excerpt

Human T cells are central to physiological immune homeostasis, which protects us from pathogens without collateral autoimmune inflammation. They are also the main effectors in most current cancer immunotherapy strategies 1 . Several decades of work have aimed to genetically reprogram T cells for therapeutic purposes 2–5 , but as human T cells are resistant to most standard methods of large DNA insertion these ap...

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Literature Corpus work: e379bd17-8bc2-5383-9877-4250697943c3
DOI: 10.1101/183418

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