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Immortalization and functional screening of natively paired human T cell receptor repertoires

30 Dec 2021

Abstract excerpt

Functional analyses of the T cell receptor (TCR) landscape can reveal critical information about protection from disease and molecular responses to vaccines. However, it has proven difficult to combine advanced next-generation sequencing technologies with methods to decode the peptide-major histocompatibility complex (pMHC) specificity of individual TCRs. We developed a new high-throughput approach to enable...

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PMID: 35174859
DOI: 10.1093/protein/gzab034

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