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Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy

1 Aug 2021

Abstract excerpt

Adoptive transfer of T cells expressing a transgenic T cell receptor (TCR) has the potential to revolutionize immunotherapy of infectious diseases and cancer. However, the generation of defined TCR-transgenic T cell medicinal products with predictable in vivo function still poses a major challenge and limits broader and more successful application of this "living drug." Here, by studying 51 different TCRs, we...

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PMID: 34467251
DOI: 10.1016/j.xcrm.2021.100374

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