Article

Immortalization and Functional Screening of Natively Paired Human T Cell Receptor Repertoires

2021-10-21

Abstract excerpt

Functional analyses of the T cell receptor (TCR) landscape can reveal critical information about protection from disease and molecular responses to vaccines. However, it has proven difficult to combine advanced next-generation sequencing technologies with methods to decode the peptide-major histocompatibility complex (pMHC) specificity of individual TCRs. Here we developed a new high-throughput approach to enable...

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Literature Corpus work: a74cc288-0754-56de-b014-7f5dc33d9272
DOI: 10.1101/2021.10.19.465057

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