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Engineering Strategies to Enhance TCR-Based Adoptive T Cell Therapy

18 Jun 2020

Abstract excerpt

T cell receptor (TCR)-based adoptive T cell therapies (ACT) hold great promise for the treatment of cancer, as TCRs can cover a broad range of target antigens. Here we summarize basic, translational and clinical results that provide insight into the challenges and opportunities of TCR-based ACT. We review the characteristics of target antigens and conventional αβ-TCRs, and provide a summary of published clinical...

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PMID: 32570906
DOI: 10.3390/cells9061485

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