Article

Miniaturized CAR knocked onto CD3ε extends TCR function with CAR specificity under control of endogenous TCR signaling cascade

2023-06-01

Abstract excerpt

Immunotherapy using TCR and especially CAR transgenic T cells is a rapidly advancing field with the potential to become standard of care for the treatment of multiple diseases. While all current FDA approved CAR T cell products are generated using lentiviral gene transfer, extensive work is put into CRISPR/Cas mediated gene delivery to develop the next generation of safer and more potent cell products. One limitat...

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Literature Corpus work: 382ad968-6169-5bf2-b63e-e6e3f7e5d9b4
DOI: 10.1101/2023.05.30.542829

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