Article

A universal platform for simultaneous TCRα/β removal enables safer and more potent TCR therapies and autoimmune modeling

2026-02-20

Abstract excerpt

Adoptive T-cell therapies using tumour-specific T-cell receptors (TCRs) are limited by competition with endogenous receptors, which impairs efficacy and poses risks of off-target autoreactivity. Here we present a CRISPR-based platform that completely and selectively eliminates both endogenous TCR-α and -β chains without affecting introduced transgenic TCRs, irrespective of codon optimization. This approach achieve...

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Identifiers and source

Literature Corpus work: 6a5b900e-9398-54eb-b5cc-177aca2d1059
DOI: 10.64898/2026.02.19.706929

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