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Article

YAP1 Expression in SCLC Defines a Distinct Subtype With T-cell-Inflamed Phenotype.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Mar 2021

Owonikoko Taofeek K, Dwivedi Bhakti, Chen Zhengjia, Zhang Chao, Barwick Benjamin, Ernani Vinicius, Zhang Guojing, Gilbert-Ross Melissa, Carlisle Jennifer, Khuri Fadlo R, Curran Walter J, Ivanov Andrey A, Fu Haian, Lonial Sagar, Ramalingam Suresh S, Sun Shi-Yong, Waller Edmund K, Sica Gabriel L

Abstract excerpt

INTRODUCTION: The clinical and biological significance of the newly described SCLC subtypes, SCLC-A, SCLC-N, SCLC-Y, and SCLC-P, defined by the dominant expression of transcription factors ASCL1, NeuroD1, YAP1, and POU2F3, respectively, remain to be established. METHODS: We generated new RNA sequencing expression data from a discovery set of 59 archival tumor samples of neuroendocrine tumors and new protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33248321
DOI: 10.1016/j.jtho.2020.11.006
PMCID: PMC7920957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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