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Article

YAP1 status defines two intrinsic subtypes of LCNEC with distinct molecular features and therapeutic vulnerabilities

2023-12-20

Abstract excerpt

Large cell neuroendocrine carcinoma (LCNEC) is a high-grade neuroendocrine malignancy that, like the more common small cell lung cancer (SCLC), is associated with an absence of druggable oncogenic driver mutations, a clinically aggressive disease course, and dismal prognosis. In contrast to SCLC, however, there is little evidence to guide optimal treatment strategies which are, instead, often adapted from SCLC and...

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Literature Corpus work
aaaefddf-7de4-5725-a4e5-7ad27cf9b1cd
DOI
10.1101/2023.12.19.572449
Open publication

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YAP1 status defines two intrinsic subtypes of LCNEC with distinct molecular features and therapeutic vulnerabilitiesDOI 10.1101/2023.12.19.572449
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